新学術領域研究(研究領域提案型) 脳タンパク質老化と認知症制御

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論文 A03

A03-1

  1. Fox RG, Lytle NK, Park FD, Bajaj J, Koechlein CS, Yano M, Ito T, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM and Reya T: Image based identification and targeting of cancer stem cells in pancreatic adenocarcinoma.Nature, 2016. (in press)
  2. Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Eiji Ikeda E, Kazuo Okanoya K, Seino KI, Saya H, Okano H and Miura K: Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.Nature Communication, 2016. (in press)
  3. Narumi S., Amano, S., Okano H., Miyake N, Hasegawa T. et al.: SAMD9 mutations cause a novel multisystem disorder (MIRAGE syndrome) and are associated with loss of chromosome 7.Nature Genetics, 2016. (In Press)
  4. Bertolin AP, Katz MJ, Yano M, Pozzi B, Acevedo JM, Blanco-Obregón D, Gándara L, Sorianello E, Kanda H, Okano H, Srebrow A, Wappner P.: Musashi mediates translational repression of the Drosophila hypoxia inducible factor.Nucleic Acids Res. 2016 May 3. pii: gkw372. [Epub ahead of print]
  5. Ouchi T, Morikawa S, Shibata S, Fukuda K, Okuno H, Fujimura T, Ohyama M, Akamatsu W, Nakagawa T, Okano H.: LNGFR+THY-1+ human pluripotent stem cells-derived neural crest-like cells have potential to develop into mesenchymal stem cells.Differentiation, 2016. (In Press)
  6. Bamba Y, Shofuda T, Kato M, Ritsuko K. Pooh RK, Kanemura Y, Okano H et al..: In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.Mol Brain, 2016. (In Press)
  7. Shimazaki T, Okano H. Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation.Aging and Mechanism of Disease.2016;2, 15014.
  8. Isoda M, Kohyama J, Iwanami A, Sanosaka T, Sugai K, Yamaguchi R, Matsumoto T, Nakamura M, Okano H. Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions.Neurosci Res. 2016 Apr 12. [Epub ahead of print] PMID: 27083781.
  9. Andoh-Noda T, Inouye MO, Miyake K, Kubota T, Okano H, Akamatsu W. Modeling Rett syndrome using human induced pluripotent stem cells.CNS Neurol Disord Drug Targets. 2016.[Epub ahead of print] PMID: 27071793.
  10. Hosoya M, Fujioka M, Kobayashi R, Okano H, Ogawa K. Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation.Neurosci Res. 2016. [Epub ahead of print] PMID: 27091614.
  11. Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.PLoS One. 2016;11(4):e0153957. 2016.
  12. Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H. Application of q-Space Diffusion MRI for the Visualization of White Matter.J Neurosci. 2016;36(9):2796-808.
  13. Fujimura T, Shibata S, Shimojima N, Morikawa Y, Okano H, Kuroda T. Fluorescence Visualization of the Enteric Nervous Network in a Chemically Induced Aganglionosis Model.PLoS One. 2016;11(3):e0150579.
  14. chiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H. Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.Stem Cell Reports. 2016;6(4):496-510. 2016.
  15. Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K, Toda M. MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53.Cancer Res. 2016;pii: canres.1011.2015. [Epub ahead of print] PMID: 26980763.
  16. Hosoya M, Fujioka M, Ogawa K, Okano H. Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.Sci Rep. 2016;6:22250.
  17. Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H. Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling.Stem Cell Reports. 2016;6(3):422-35.
  18. Morikawa S, Ouchi T, Shibata S, Fujimura T, Kawana H, Okano H, Nakagawa T. Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research.Stem Cells Int. 2016;2016:2849879.
  19. Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T. Erratum: Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.Sci Rep. 2016;6:20268.
  20. Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S. MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.Elife . 2016;5.
  21. Nishiyama Y, Iwanami A, Kohyama J, Itakura G, Kawabata S, Sugai K, Nishimura S, Kashiwagi R, Yasutake K, Isoda M, Matsumoto M, Nakamura M, Okano H. Safe and efficient method for cryopreservation of human induced pluripotent stem cell-derived neural stem and progenitor cells by a programmed freezer with a magnetic field.Neurosci Res. 2016. [Epub ahead of print] PMID:26804710.
  22. Yano M, Hayakawa-Yano Y, Okano H. RNA Regulation went wrong in neurodevelopmental disorders: the example of Msi/Elav RNA binding proteins.Int J Dev Neurosci. 2016;[Epub ahead of print] PMID:26796049.
  23. Hasegawa M, Hara-Miyauchi C, Ohta H, Sakimura K, Okano H, Okano HJ. Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.Neurosci Res. 2016;106:12-22.
  24. Kobayashi R, Takahashi-Fujigasaki J, Shiozawa S, Hara-Miyauchi C, Inoue T, Okano HJ, Sasaki E, Okano H. α-synuclein aggregation in the olfactory bulb of middle-aged common marmoset.Neurosci Res. 2016;106:55-61.
  25. Lin ZY, Hikabe O, Suzuki S, Hirano T, Siomi H, Sasaki E, Imamura M, Okano H. Sphere-formation culture of testicular germ cells in the common marmoset, a small New World monkey.Primates. 2016;57(1):129-35.
  26. Yasui T, Mabuchi Y, Toriumi H, Ebine T, Niibe K, Houlihan DD, Morikawa S, Onizawa K, Kawana H, Akazawa C, Suzuki N, Nakagawa T, Okano H, Matsuzaki Y. Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration.J Dent Res. 2016;95(2):206-14. 2016
  27. Grants JM, Ying LT, Yoda A, You CC, Okano H, Sawa H, Taubert S. The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans.Genetics. 2015;202(2):583-99.
  28. Kawabata S, Takano M, Numasawa-Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, Sugai K, Nishimura S, Iwai H, Isoda M, Shibata S, Kohyama J, Iwanami A, Toyama Y, Matsumoto M, Nakamura M, Okano H. Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury.Stem Cell Reports. 2015;6(1):1-8.
  29. Shimojo D, Onodera K, Doi-Torii Y, Ishihara Y, Hattori C, Miwa Y, Tanaka S, Okada R, Ohyama M, Shoji M, Nakanishi A, Doyu M, Okano H, Okada Y. Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.Mol Brain.. 2015;8(1):79.
  30. Sato K, Kuroki Y, Kumita W, Fujiyama A, Toyoda A, Kawai J, Iriki A, Sasaki E, Okano H, Sakakibara Y. Resequencing of the common marmoset genome improves genome assemblies and gene-coding sequence analysis.Sci Rep . 2015;5:16894.
  31. Yamada I, Hikishima K, Miyasaka N, Kato K, Kojima K, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H. Gastric carcinoma: evaluation with diffusion-tensor MR imaging and tractography ex vivo.Magn Reson Imaging. 2015.
  32. Nakata M, Yamamoto S, Okada T, Darambazar G, Okano H, Ozawa K, Yada T. IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin.Int J Obes(Lond). 2015 Oct 5. doi: 10.1038/ijo.2015.201. [Epub ahead of print]
  33. Kanzaki S, Watanabe K, Fujioka M, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K. Novel in vivo imaging analysis of an inner ear drug delivery system: drug availability in inner ear following different dose of systemic drug injections.Hear Res. 2015;330(Pt A):142-6.
  34. Imaizumi K, Sone T, Ibata K, Fujimori K, Yuzaki M, Akamatsu W, Okano H. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.Stem Cell Reports. 2015;5(6):1010-22.
  35. Kohro Y, Sakaguchi E, Tashima R, Tozaki-Saitoh H, Okano H, Inoue K, Tsuda M. A new minimally-invasive method for microinjection into the mouse spinal dorsal horn.Sci Rep. 2015;5:14306.
  36. Yamada I, Hikishima K, Miyasaka N, Kato K, Ito E, Kojima K, Kawano T, Kobayashi D, Eishi Y, Okano H. q-space MR imaging of gastric carcinoma ex vivo: Correlation with histopathologic findings.Magn Reson Med. 2015. [Epub ahead of print] PMID: 26332305
  37. Ohtsuka T, Yano M, Okano H. Acute reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment.Biochem Biophys Res Commun. 2015;466(1):46-51. 2015.
  38. Shibata S, Murota Y, Nishimoto Y, Yoshimura M, Nagai T, Okano H, Siomi MC. Immuno-Electron Microscopy and Electron Microscopic In Situ Hybridization for Visualizing piRNA Biogenesis Bodies in Drosophila Ovaries.Methods Mol Biol. 2015;1328:163-78.
  39. Sugai K, Nishimura S, Kato-Negishi M, Onoe H, Iwanaga S, Toyama Y, Matsumoto M, Takeuchi S, Okano H, Nakamura M. Neural stem/progenitor cell-laden microfibers promote transplant survival in a mouse transected spinal cord injury model.J Neurosci Res. 2015;93(12):1826-38.
  40. Masuda H, Maruyama T, Gargett CE, Miyazaki K, Matsuzaki Y, Okano H, Tanaka M. Endometrial Side Population Cells: Potential Adult Stem/Progenitor Cells in Endometrium.Biol Reprod. 2015;93(4):84.
  41. Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T, Okano H. MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells.Stem Cell Reports. 2015;5(3):365-77.
  42. Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.Nat Med. 2015;21(8):927-31.
  43. Yokota K, Kobayakawa K, Kubota K, Miyawaki A, Okano H, Ohkawa Y, Iwamoto Y, Okada S. Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury.Stem Cell Reports. 2015;5(2):264-77.
  44. Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T. CD34 and CD49f Double-Positive and Lineage Marker-Negative Cells Isolated from Human Myometrium Exhibit Stem Cell-Like Properties Involved in Pregnancy-Induced Uterine Remodeling.Biol Reprod. 2015;93(2):37.
  45. Kondo T, Yoshihara Y, Yoshino-Saito K, Sekiguchi T, Kosugi A, Miyazaki Y, Nishimura Y, Okano HJ, Nakamura M, Okano H, Isa T, Ushiba J. Histological and electrophysiological analysis of the corticospinal pathway to forelimb motoneurons in common marmosets.Neurosci Res. 2015;98:35-44.
  46. Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H. I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.Hum Mol Genet. 2015;24(17):4879-900.
  47. Okano H, Miyawaki A, Kasai K. Brain/MINDS: brain-mapping project in Japan.Philos Trans R Soc Lond B Biol Sci. 2015;370(1668).
  48. Belmonte JC, Callaway EM, Churchland P, Caddick SJ, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J1, Zhang F. Brains, Genes, and Primates.Neuron. 86(3):617-631. 2015.
  49. Andoh-Noda T, Akamatsu W, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H. Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.Mol Brain. 2015;8(1):31.
  50. Hikishima K, Ando K, Komaki Y, Kawai K, Yano R, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H. Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson’s disease model.Neuroscience. 2015;300:585-92.
  51. Ishii K, Suzuki N, Mabuchi Y, Ito N, Kikura N, Fukada SI, Okano H, Takeda S, Akazawa C. Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation during Muscle Regeneration.Stem Cells. 2015;33(10):3017-27.
  52. Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H. Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.Stem Cells Transl Med. 2015;4(7):708-19.
  53. Yu-Ching Lin Z, Hirano T, Shibata S, Seki NM, Kitajima R, Sedohara A, Siomi MC, Sasaki E, Siomi H, Imamura M, Okano H. Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development.Dev Biol. 2015;400(1):43-58.
  54. Yamamoto-Hino M, Muraoka M, Kondo S, Ueda R, Okano H, Goto S. Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation.Proc Natl Acad Sci U S A. 2015;112(18):5809-14.
  55. Tsuboi D, Kuroda K, Tanaka M, Namba T, Iizuka Y, Taya S, Shinoda T, Hikita T, Muraoka S, Iizuka M, Nimura A, Mizoguchi A, Shiina N, Sokabe M, Okano H, Mikoshiba K, Kaibuchi K. Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.Nat Neurosci. 2015;18(5):698-707.
  56. Takata N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, Mimura M, Okano H, Tanaka KF. Optogenetic Activation of CA1 Pyramidal Neurons at the Dorsal and Ventral Hippocampus Evokes Distinct Brain-Wide Responses Revealed by Mouse fMRI.PLoS One . 2015;10(3):e0121417.
  57. Tokuno H, Watson C, Roberts A, Sasaki E, Okano H. Marmoset Neuroscience.Neurosci Res. 2015;93:1-2.
  58. Kano SI, Yuan M, Cardarelli RA, Maegawa G, Horiuchi Y, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O’Donnell P, Sawa A, Kai M. Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.Curr Mol Med. 2015;15(2):138-45.
  59. Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H. Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition.Stem Cell Reports. 2015;4(3):360-73. 2015.
  60. Fujioka M, Okano H, Edge AS. Manipulating cell fate in the cochlea: a feasible therapy for hearing loss.Trends Neurosci. 2015;38(3):139-144.
  61. Hayashi S, Yano M, Igarashi M, Okano HJ, Okano H. Alternative Role of HuD Splicing Variants in Neuronal Differentiation.J Neurosci Res. 2015;93(3):399-409.
  62. Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Controlling Immune Rejection Is a Fail-Safe System against Potential Tumorigenicity after Human iPSC-Derived Neural Stem Cell Transplantation.PLoS One. 2015;10(2):e0116413.
  63. Yamada I, Miyasaka N, Hikishima K, Tokairin Y, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H. Ultra-high-resolution MR imaging of esophageal carcinoma at ultra-high field strength (7.0 T) ex vivo: Correlation with histopathologic findings.Magn Reson Imaging. 2015;33(4):413-9.
  64. Hikishima K, Ando K, Yano R, Kawai K, Komaki Y, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H. Parkinson Disease: Diffusion MR Imaging to Detect Nigrostriatal Pathway Loss in a Marmoset Model Treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Radiology. 2015;275(2):430-7.
  65. Yamada I, Miyasaka N, Hikishima K, Kato K, Kojima K, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H. Gastric Carcinoma: Ex Vivo MR Imaging at 7.0 T-Correlation with Histopathologic Findings.Radiology. 2015;275(3):841-8.
  66. Yano M, Ohtsuka T, Okano H. RNA-binding protein research with transcriptome-wide technologies in neural development.Cell Tissue Res. 2015;359(1):135-44.
  67. Fujioka M, Okano H, Ogawa K. Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss.Front Pharmacol. 2014;5:287. 2014.
  68. Shibata S, Komaki Y, Seki F, Inouye MO, Nagai T, Okano H. Connectomics: comprehensive approaches for whole-brain mapping.Microscopy(Oxf). 2014;64(1):57-67. 2014.
  69. Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, Nakamura M, Okano H. BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2.Neurorehabil Neural Repair. 2014;29(7):677-89.
  70. Takemi M, Kondo T, Yoshino-Saito K, Sekiguchi T, Kosugi A, Kasuga S, Okano HJ, Okano H, Ushiba J. Three-dimensional motion analysis of arm-reaching movements in healthy and hemispinalized common marmosets.Behav Brain Res. 2014; 275:259-68. 2014.
  71. Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Iakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson AJ, Okano H, Nakamura M. Global gene expression analysis following spinal cord injury in non-human primates.Exp Neurol. 2014;261:171-9.
  72. Zhang H, Tan E, Suzuki Y, Hirose Y, Kinoshita S, Okano H, Kudoh J, Shimizu A, Saito K, Watabe S, Asakawa S. Dramatic improvement in genome assembly achieved using doubled-haploid genomes.Sci Rep. 2014;4:6780.
  73. Kuwako K, Nishimoto Y, Kawase S, Okano HJ, Okano H. Cadherin-7 Regulates Mossy Fiber Connectivity in the Cerebellum.Cell Rep. 2014;9(1):311-23.
  74. Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T. Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses.Biol Psychiatry. 2014;78(2):116-25.
  75. Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung’s disease.Cytotechnology. 2014;67(4):661-70.
  76. Okano H. Stem cell research and regenerative medicine in 2014: first year of regenerative medicine in Japan.Stem Cells Dev. 2014;23(18):2127-2128. 2014.
  77. Kawase S, Kuwako K, Imai T, Renault-Mihara F, Yaguchi K, Itohara S, Okano H. Rfx Transcription Factors Control Musashi1 Transcription in Mouse Neural Stem/Progenitor Cells.Stem Cells Dev. 2014;23(18):2250-61.
  78. Yamada I, Hikishima K, Miyasaka N, Tokairin Y, Kawano T, Ito E, Kobayashi D, Eishi Y, Okano H, Shibuya H. Diffusion-tensor MRI and tractography of the esophageal wall ex vivo.J Magn Reson Imaging. 2014;40(3):567-76.
  79. Okano H, Mitra P. Brain-mapping projects using the common marmoset.Neurosci Res. 2014;93:3-7.
  80. Matsuzaki Y, Mabuchi Y, Okano H. Leptin Receptor Makes Its Mark on MSCs.Cell Stem Cell. 2014;15(2):112-4. 2014.
  81. Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H. Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice.Stem Cell Reports. 2014;3(2):242-9.
  82. Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC. Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly.Cell Rep. 2014;8(1):103-13.
  83. Yamada I, Hikishima K, Miyasaka N, Kawano T, Tokairin Y, Ito E, Kobayashi D, Eishi Y, Okano H. Esophageal Carcinoma: Ex Vivo Evaluation with Diffusion-Tensor MR Imaging and Tractography at 7 T.Radiology. 2014;272(1):164-73.
  84. Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.Mol Brain. 2014;7(1):45.
  85. Kato M, Okanoya K, Koike T, Sasaki E, Okano H, Watanabe S, Iriki A. Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain.Brain Lang. 2014; 133:26-38.
  86. Fukuda T, Takeda S, Xu R, Sato T, Bando W, Ochi H, Sunamura S, Fujita K, Shinomiya K, Okano H, Kimura A, Enomoto M, Okawa A, Itoh H.: Sema3A regulates bone mass accrual through sensory innervations.Nature. 2013;497:490-3.
  87. Okano H, Nakamura M, Yoshida K, Okada Y, Tsuji O, Nori S, Ikeda E, Yamanaka S, Miura K.: Steps toward safe cell therapy using induced pluripotent stem cells. Circulation Research. 2013;112:523-533.
  88. Ito D, Okano H, Suzuki N: Accelerating progress in iPS cell research for neurological diseases. Ann. Neurol. 2012;72:167-74.
  89. Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Masaya N, Okano H. Grafted human induced pluripotent stem cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice. Proc.Natl.Acad.Sci.USA. 2011;108:16825-30.
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A03-2

  1. Higuchi H, Ji B, Maeda J, Sahara N, Suhara T. In vivo imaging of neuroinflammation in Alzheimer’s disease.Clinical and Experimental Neuroimmunology in press. 2016
  2. Dulal HP, Nagae M, Ikeda A, Morita-Matsumoto K, Adachi Y, Ohno N, Yamaguchi Y. Enhancement of solubility and yield of a β-glucan receptor Dectin-1 C-type lectin-like domain in Escherichia coli with a solubility-enhancement tag.Protein Expr. Purif. 2016;123, 97-104.
  3. Nagae M, Ikeda A, Hanashima S, Kojima T, Matsumoto N, Yamamoto K, Yamaguchi Y. Crystal structure of human dendritic cell inhibitory receptor (DCIR) C-type lectin domain reveals the binding mode with N-glycan.FEBS Lett. 2016;590(8), 1280-8.
  4. Aoyagi T, Ohira S, Fuse S, Uzawa J, Yamaguchi Y, Tanaka H. The α-glycosidation of partially unprotected N-acetyl and N-glycolyl sialyl donors in the absence of a nitrile solvent effect.Chem. Eur J. 2016;22(20), 6968-73.
  5. Yoshihara A, Fukatsu M, Hoshi K, Ito H, Nollet K, Yamaguchi Y, Ishii R, Tokuda T, Miyajima M, Arai H, Kato T, Furukawa K, Arai H, Kikuchi A, Takeda A, Ugawa Y, Hashimoto Y*. Subgroup differences in “brain-type” transferrin and alpha-synuclein in Parkinson’s disease and multiple system atrophy.J. Biochem. 2016. [Epub ahead of print]
  6. Nagae M, Kanagawa M, Morita-Matsumoto K, Hanashima S, Kizuka Y, Taniguchi N, Yamaguchi Y. Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins.Sci. Rep. 2016;6, 22973.
  7. Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T. Identification of a post-translational modification with ribitol-phosphate and its defect in muscular dystrophy.Cell Rep. 2016;14(9), 2209-23.
  8. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gartner F, Sanches JM, Ruppert T, Miyoshi E., Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Pinho SS. Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer.Oncogene. 2016;35(13), 1619-31.
  9. Kimura Y, Endo H, Ichise M, Shimada H, Seki C, Ikoma Y, Shinotoh H, Yamada M, Higuchi M, Zhang M-R, Suhara T. A new method to quantify tau pathologies with (11)C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter.EJNMMI research. 2016;6(1), 24, DOI:10.1186/s13550-016-0182-y.
  10. Kimura Y, Seki C, Ikoma Y, Ichise M, Kawamura K, Takahata K, Moriguchi S, Nagashima T, Ishii T, Kitamura S, Niwa F, Endo H, Yamada M, Higuchi M, Zhang M-R, Suhara T. [(11)C]TASP457, a novel PET ligand for histamine H3 receptors in human brain.European Journal of Nuclear Medicine and Molecular Imaging. 2016;DOI:10.1007/s00259-016-3332-6.
  11. Koga K, Maeda J, Tokunaga M, Hanyu M, Kawamura K, Ohmichi M, Nakamura T, Nagai Y, Seki C, Kimura Y, Minamimoto T, Zhang M-R, Fukumura T, Suhara T, Higuchi M. Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors.EJNMMI Research. 2016;6(1), 11, DOI:10.1186/s13550-016-0170-2.
  12. Moraga A, Gómez-Vallejo V, Isabel Cuartero M, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo J.M., Higuchi M, Llop J, Moro M. Á., Martín A, Lizasoain I. Imaging the role of TLR4 on cell proliferation and inflammation after cerebral ischemia by PET.Journal of Cerebral Blood Flow and Metabolism. 2016;DOI:10. 1177/0271678X15627657Goda.
  13. Goda N, Yokoi I, Tachibana A, Minamimoto T, Komatsu H. Crossmodal association of visual and haptic material properties of objects in the monkey ventratl visual cortex.Curr. Biol. 2016;26(7): 928-34.
  14. McCairn KW, Nagai Y, Hori Y, Kikuchi E, Ninomiya T, Suhara T, Lee J-Y, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M. A primary role for nucleus accumbens and related limbic network in vocal ticsNeuron. 2016;89(2), 300 – 307.
  15. Eldridge MAG, Lerchner W, Saunders RC, Kaneko H, Krausz KW, Gonzalez FJ, Ji B, Higuchi M, Minamimoto T, Richmond BJ. Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.Nature Neuroscience. 2016;19(1), 37 – 39, DOI:doi:10.1038/nn. 4192.
  16. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gartner F, Sanches JM, Ruppert T, Miyoshi E., Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Pinho SS. Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer.Oncogene. 2016;35(13), 1619-31.
  17. Shimojo M, Higuchi M, Suhara T, Sahara N. Imaging Multimodalities for Dissecting Alzheimer’s Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging.Frontiers in Neuroscience. 2015;9.
  18. Kimura Y, Ichise M, Ito H, Shimada H, Ikoma Y, Seki C, Takano H, Kitamura S, Shinotoh H, Kawamura K, Zhang M-R, Sahara N, Suhara T, Higuchi M. PET Quantification of Tau Pathology in Human Brain with 11C-PBB3.Journal of Nuclear Medicine. 2015;56(9), 1359 – 1365.
  19. Yagi H, Zhang Y, Yagi-Utsumi M, Yamaguchi T, Iida S, Yamaguchi Y, Kato K. Backbone ¹H, ¹³C, and ¹⁵N resonance assignments of the Fc fragment of human immunoglobulin G glycoprotein.Biomol. NMR Assign. 2015;9(2), 257-60.
  20. Nagae M, Yamaguchi Y. Sugar recognition and protein–protein interaction of mammalian lectins conferring diverse functions.Curr. Opin. Struct. Biol. 2015;34, 108-115.
  21. Ohira S, Yamaguchi Y, Takahashi T, Tanaka H. The chemoselective O-glycosylation of alcohols in the presence of a phosphate diester and its application to the synthesis of oligomannosylated phosphatidyl inositols.Tetrahedron. 2015;71(37), 6602-11.
  22. Kawatani M, Fukushima Y, Kondoh Y, Honda K, Sekine T, Yamaguchi Y, Taniguchi N, Osada H. Identification of matrix metalloproteinase inhibitors by chemical arrays. Biosci. Biotechnol.Biochem. 2015;79(10), 1597-602.
  23. Hanashima S, Gotze S, Liu Y, Ikeda A, Kojima-Aikawa K, Taniguchi N, Silva DV, Feizi T, Seeberger PH, Yamaguchi Y. Defining the interaction of human soluble lectin ZG16p and mycobacterial phosphatidylinositol mannosides.ChemBiocChem. 2015;16(10), 1502-11.
  24. Matsumoto Y, Saito T, Hoshi K, Ito H, Kariya Y, Nagae M, Yamaguchi Y, Hagiwara Y, Kinoshita N, Wada I, Saito K, Honda T, Hashimoto Y. In situ visualization of a glycoform of transferrin: localization of α2,6-sialylated transferrin in the liver.J. Biochem. 2015;157(4), 211-6.
  25. Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y. Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling.Oncogene. 2015;34(7), 838-45.
  26. Garénaux E, Kanagawa M, Tsuchiyama T, Hori K, Kanazawa T, Goshima A, Chiba M, Yasue H, Ikeda A, Yamaguchi Y, Sato C, Kitajima K. Discovery, Primary and Crystal Structures, and Capacitation-Related Properties of a Prostate-Derived Heparin-Binding Protein WGA16 from Boar Sperm.J. Biol. Chem . 2015;290(9), 5484-501.
  27. Sato S, Takeuchi R, Yagi-Utsumi M, Yamaguchi T, Yamaguchi Y, Kato K, Fujita M. A Self-Assembled, π-Stacked Complex as a Finely-Tunable Magnetic Aligner for Biomolecular NMR Applications.Chem. Commun. 2015;51, 2540-3.
  28. Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease.EMBO Mol Med. 2015;7(2), 175-89.
  29. Takuwa H, Maeda J, Ikoma Y, Tokunaga M, Wakizaka H, Uchida S, Kanno I, Taniguchi J, Ito H, Higuchi M. [(11) C]Raclopride binding in the striatum of minimally restrained and free-walking awake mice in a positron emission tomography study.Synapse(New York, N.Y.). 2015;69(12), 600 – 606, DOI:10.1002/syn.21864
  30. Xie L, Maeda J, Kumata K, Yui J, Zhang Y, Hatori A, Nengaki N, Wakizaka H, Fujinaga M, Yamasaki T, Shimoda Y, Higuchi M, Suhara T, Wang F, Zhang M-R. Development of 1-N-(11)C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan.Scientific Reports. 2015;5, 16417, DOI:doi:10.1038/srep16417
  31. Oi N, Tokunaga M, Suzuki M, Nagai Y, Nakatani Y, Yamamoto N, Maeda J, Minamimoto T, Zhang M-R, Suhara T, Higuchi M. Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) Receptors.Journal of Medicinal Chemistry Manuscript. 2015;58(21), 8444 – 8462, DOI:10.1021/acs.jmedchem.5b00712
  32. Hashimoto H, Kawamura K, Takei M, Igarashi N, Fujishiro T, Shiomi S, Watanabe R, Muto M, Furutsuka K, Ito T, Yamasaki T, Yui J, Nemoto K, Kimura Y, Higuchi M, Zhang M-R. Identification of a major radiometabolite of [11C]PBB3.Nuclear Medicine and Biology。2015;42(12), 905 – 910, DOI:doi:10.1016/j.nucmedbio.2015.08.006
  33. Ji B, Chen C-J, Bando K, Ashino H, Shiraishi H, Sano H, Kasahara H, Minamizawa T, Yamada K, Ono M, Zhang M-R, Seki C, Farde L, Suhara T, Higuchi M. Distinct Binding of Amyloid Imag.ing Ligands to Unique Amyloid-β Deposited in the Presubiculum of Alzheimer’s Disease.Journal of Neurochemitry.2015-08
  34. Shimada H, Shinotoh H, Ota T, Sato K, Yamada M, Fukushi K, Irie T, Zhang M-R, Higuchi M, Kuwabara S, Suhara T. Dementia with Lewy bodies can be well-differentiated from Alzheimer’s disease by measurement of brain acetylcholinesterase activity – A [11C]MP4A PET study.International Journal of Geriatric Psychiatry. 2015;30(11), 1105 – 1113, DOI:10.1002/gps.4338
  35. Tiwari A, Ji B, Yui J, Fujinaga M, Yamasaki T, Xie L, Luo R, Shimoda Y, Kumata K, Zhang Y, Hatori A, Maeda J, Higuchi M, Wang F, Zhang M-R. [(18)F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain.Theranostics. 2015;5(9), 961 – 969.
  36. Martin A, Szcaupak B, Gomez-Vallejo V, Domercq M, Cano A, Padro D, Munoz C, Higuchi M, Matute C, Llop J. In Vivo PET Imaging of the α4β2 Nicotinic Acetylcholine Receptor As a Marker for Brain Inflammation after Cerebral Ischemia.Journal of Neuroscience. 2015;35(15), 5998 – 6009, DOI:10.1523/JNEUROSCI. 2015;3670-14.
  37. Chen C-J, Bando K, Ashino H, Taguchi K, Shiraishi H, Shima K, Fujimoto O, Kitamura C, Matsushima S, Uchida K, Nakahara Y, Kasahara H, Minamizawa T, Jiang C, Zhang M-R, Ono M, Tokunaga M, Suhara T, Higuchi M, Yamada K, Ji B. In Vivo SPECT Imaging of Amyloid-β Deposition with Radioiodinated Imidazo[1,2-a]pyridine Derivative DRM106 in Mouse Model of Alzheimer’s Disease.JNM/JNMT. 2015;56(1), 120 – 126, DOI:10.2967/jnumed. 2015;114.146944
  38. Tateno A, Sakayori T, Higuchi M, Suhara T, Ishihara K, Kumita S, Suzuki H, Okubo Y. Amyloid imaging with [(18) F]florbetapir in geriatric depression: early-onset versus late-onset.International journal of geriatric psychiatry. 2015; 30(7), 720 – 728, DOI:10.1002/gps.4215
  39. Tateno A, Sakayori T, Kawashima Y, Higuchi M, Suhara T, Mizumura S, Mintun MA, Skovronsky DM, Honjo K, Ishihara K, Kumita S, Suzuki H, Okubo Y. Comparison of imaging biomarkers for Alzheimer’s disease: amyloid imaging with [(18) F]florbetapir positron emission tomography and magnetic resonance imaging voxel-based analysis for entorhinal cortex atrophy.International journal of geriatric psychiatry. 2015;30(5), 505 – 513, DOI:10.1002/gps.417Endo
  40. T, Saijo T, Haneda E, Maeda J, Tokunaga M, Zhang M-R, Kannami A, Asai H, Suzuki M, Suhara T, Higuchi M. Quantification of central substance P receptor occupancy by aprepitant using small animal positron emission tomography.The international journal of neuropsychopharmacology. 2015;18(2), 1 – 10.
  41. Matsumoto KI, Yamasaki T, Nakamura M, Ishikawa J, Ueno M, Nakanishi I, Sekita A, Ozawa Y, Kamada T, Aoki I, Yamada KI. Brain contrasting ability of blood-brain-barrier-permeable nitroxyl contrast agents for magnetic resonance redox imaging.Magn Reson Med. 2015
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  49. Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A. Biochemical distribution of tau protein in synaptosomal fraction of transgenic mice expressing human P301L tau.Frontiers in Neurology. 2014;11;5:26:1.
  50. Bailey RM, Howard J, Knight J, Sahara N, Dickson DW, and Lewis J. Effects of the C57BL/6 strain background on tauopathy progression in the tTg4510 mouse model.Mol Neurodegener. 2014;15;9(1):8.
  51. Ren Y, Lin W-L, Sanchez L, Ceballos C, Polydoro M, Spires-Jones TL, Hyman BT, Dickson DW, Sahara N. Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.J. Alzheimer’s Disease. 2014;38(3):589-600.
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  53. Satoh T, Sumiyoshi A, Yagi-Utsumi M, Sakata E, Sasakawa H, Kurimoto E, Yamaguchi Y, Li W, Joazerio CA P, Hirokawa T, Kato K. Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity.FEBS Lett. 2014;588, 4422-30.
  54. Nagae M, Morita-Matsumoto K, Kato M, Kaneko MK, Kato Y, Yamaguchi Y. A platform of C-type lectin-like receptor CLEC-2 for binding O-glycosylated podoplanin and nonglycosylated rhodocytin.Structure. 2014;22(12), 1711-21.
  55. Sudo M, Yamaguchi Y, Späth PJ, Matsumoto-Morita K, Ong BK, Shahrizaila N, Yuki N. Different IVIG glycoforms affect in vitro inhibition of anti-ganglioside antibody-mediated complement deposition.PLoS ONE. 2014;9(9), e107772.
  56. Kawasaki N, Okumoto T, Yamaguchi Y, Takahashi N, Fridman WH, Sautès-Fridman C, Yagi H, Kato K. Site-specific classification of N-linked oligosaccharides of the extracellular regions of Fcγ receptor IIIb expressed in baby hamster kidney cells.J. Glycomics Lipidmics. 2014;4(2), 1-5.
  57. Hanashima S, Korekane H, Taniguchi N, Yamaguchi Y. Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III.Bioorg. Med. Chem. Lett. 2014;24(18), 4533-7.
  58. Pradipta AR, Tsutsui A, Ogura A, Hanashima S, Yamaguchi Y, Kurbangalieva A, Tanaka K. Microfluidic mixing of polyamine with acrolein enables the detection of the [4+4] polymerization of intermediary unsaturated imines: The properties of a cytotoxic 1,5-diazacyclooctane hydrogel.SYNLETT and SYNTHESIS. 2014;25(17), 2442-46.
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  73. Hanashima S, Ikeda A, Tanaka H, Adachi Y, Ohno N, Takahashi T, Yamaguchi Y. NMR study of short β(1,3)-glucans provides insights into the structure and interaction with Dectin-1.Glycoconj. J. 2014;31(3), 199-207.
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