新学術領域研究(研究領域提案型) 脳タンパク質老化と認知症制御

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論文 A01

A01-1

  1. Xu Y, Halievski K, Henley C, Atchison WD, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL. Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy.J Neurosci. 2016 ;36(18):5094-106. doi: 10.1523/JNEUROSCI.3485-15.2016.
  2. Shahrizaila N, Sobue G, Kuwabara S, Kim SH, Birks C, Fan DS, Bae JS, Hu CJ, Gourie-Devi M, Noto Y, Shibuya K, Goh KJ, Kaji R, Tsai CP, Cui L, Talman P, Henderson RD, Vucic S, Kiernan MC. Amyotrophic lateral sclerosis and motor neuron syndromes in Asia.J Neurol Neurosurg Psychiatry. 2016.
  3. Yokoi D, Atsuta N, Watanabe H, Nakamura R, Hirakawa A, Ito M, Watanabe H, Katsuno M, Izumi Y, Morita M, Taniguchi A, Oda M, Abe K, Mizoguchi K, Kano O, Kuwabara S, Kaji R, Sobue G; JaCALS. Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis.J Neurol. 2016;[Epub ahead of print]
  4. Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1.Neuroscience. 2016;327:20-31.
  5. Bott LC, Badders NM, Chen KL, Harmison GG, Bautista E, Shih CC, Katsuno M, Sobue G, Taylor JP, Dantuma NP, Fischbeck KH, Rinaldi C. A small-molecule Nrf1and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.Hum Mol Genet. 2016; pii: ddw073. [Epub ahead of print]
  6. Pourshafie N, Lee PR, Chen KL, Harmison GG, Bott LC, Katsuno M, Sobue G, Burnett BG, Fischbeck KH, Rinaldi C. MiR-298 counteracts mutant androgen receptor toxicity in spinal and bulbar muscular atrophy.Mol Ther. 2016;24(5):937-45.
  7. Kato T, Inui Y, Nakamura A, Ito K:Brain Fluorodeoxyglucose (FDG)PET in dementia Ageing Research Review, 2016; pii: S1568-1637(16)30011
  8. Nakashima T, Sugiura S, Naganawa S, Yasue M, Inui Y, Sakurai T, Uchida Y, Sone M, Teranishi M, Yoshida T, Ito K, Toba K. Cerumen impaction shown by brain magnetic resonance imaging in patients with cognitive impairment.Geriatr Gerontol Int. 2016; 16(3):392-5.
  9. Matsui T, Nakamura T, Utsumi A, Sasaki AT, Koike T, Yoshida Y, Harada T, Tanabe HC, Sadato N. (2016.4) The role of prosody and context in sarcasm comprehension: behavioral and fMRI evidence. Neuropsychologia, ePub ahead of print. DOI: 10.1016/j.neuropsychologia.2016.04.031.
  10. Yeung AWK, Tanabe HC, Suen JLK, Goto T (2016.4) Taste Intensity Modulates Effective Connectivity from the Insular Cortex to the Thalamus in Humans. NeuroImage, ePub ahead of print. DOI: 10.1016/j.neuroimage.2016.04.057
  11. Yoshihara K, Tanabe HC, Kawamichi H, Koike T, Yamazaki M, Sudo N, Sadato N (2016.4) “Neural correlates of fear-induced sympathetic response associated with the peripheral temperature change rate. NeuroImage, ePub ahead of print. DOI: 10.1016/j.neuroimage.2016.04.040
  12. Suzuki A, Ito Y, Kiyama S, Kunimi M, Ohira H, Kawaguchi J, Tanabe HC, Nakai T (2016.2) Involvement of the ventrolateral prefrontal cortex in learning others’ bad reputations and indelible disgust.Front. Hum. Neurosci.,10, 28. DOI: 10.3389/fnhum.2016.00028
  13. Nakamura R, Sone J, Atsuta N, Tohnai G, Watanabe H, Yokoi D, Nakatochi M, Watanabe H, Ito M, Senda J, Katsuno M, Tanaka F, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Aoki M, Hattori N, Tsuji S, Nakashima K, Kaji R, Sobue G; Japanese consortium for amyotrophic lateral sclerosis research (JaCALS). Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort.Neurobiol Aging. 2016;39:219.e1-8.
  14. Pourshafie N, Lee PR, Chen KL, Harmison GG, Bott LC, Katsuno M, Sobue G, Burnett BG, Fischbeck KH, Rinaldi C. MiR-298 counteracts mutant androgen receptor toxicity in spinal and bulbar muscular atrophy.Mol Ther. 2016;24(5):937-45.
  15. Bott LC, Badders NM, Chen KL, Harmison GG, Bautista E, Shih CC, Katsuno M, Sobue G, Taylor JP, Dantuma NP, Fischbeck KH, Rinaldi C. A small-molecule Nrf1and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.Hum Mol Genet. 2016;pii: ddw073. [Epub ahead of print]
  16. Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1.Neuroscience. 2016;327:20-31.
  17. Yokoi D, Atsuta N, Watanabe H, Nakamura R, Hirakawa A, Ito M, Watanabe H, Katsuno M, Izumi Y, Morita M, Taniguchi A, Oda M, Abe K, Mizoguchi K, Kano O, Kuwabara S, Kaji R, Sobue G; JaCALS. Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis.J Neurol. 2016. [Epub ahead of print]
  18. Shahrizaila N, Sobue G, Kuwabara S, Kim SH, Birks C, Fan DS, Bae JS, Hu CJ, Gourie-Devi M, Noto Y, Shibuya K, Goh KJ, Kaji R, Tsai CP, Cui L, Talman P, Henderson RD, Vucic S, Kiernan MC. Amyotrophic lateral sclerosis and motor neuron syndromes in Asia.J Neurol Neurosurg Psychiatry. 2016.
  19. Xu Y, Halievski K, Henley C, Atchison WD, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL. Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy.J Neurosci. 2016;36(18):5094-106. doi: 10.1523/JNEUROSCI.3485-15.2016.
  20. Kitaguchi N, Hasegawa M, Ito S, Kawaguchi K, Hiki Y, Nakai S, Suzuki N, Shimano Y, Ishida O, Kushimoto H, Kato M, Koide S, Kanayama K, Kato T, Ito K, Takahashi H, Mutoh T, Sugiyama S, Yuzawa Y. A prospective study on blood Aβ levels and the cognitive function of patients with hemodialysis: a potential therapeutic strategy for Alzheimer’s disease.Journal Neural Transm. 2015; 122(11):1593-607.
  21. Mishima A, Nihashi T, Ando Y, Kawai H, Kato T, Ito K, Terasawa T. Biomarkers Differentiating Dementia with Lewy Bodies from Other DementiasA Meta-Analysis.J Alzheimers Dis. 2015; 50(1):161-74.
  22. Ota K, Oishi N, Ito K, Fukuyama H; SEAD-J Study Group; Alzheimer’s Disease Neuroimaging Initiative. Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer’s disease. J Neurosci Methods. 2015; 256:168-83.
  23. Onishi H, Hatazawa J, Nakagawara J, Ito K, Ha-Kawa SK, Masuda Y, Sugibayashi K, Takahashi M, Kikuchi K, Katsuta N: Impact of injected dose and acquisition time on a normal database by use of 3D-SSP in SPECT images: quantitative simulation studies.Radiol Phys Technol. 2015; 8(2):224-31.
  24. Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H: Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [ 11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ 11C](R)-PK11195.Ann Nucl Med. 2015; 29(4):325-35.
  25. Ito K, Fukuyama H, Senda M, Ishii K, Maeda K, Yamamoto Y, Ouchi Y, Ishii K, Okumura A, Fujiwara K, Kato, T., Arahata Y, Washimi Y, Mitsuyama Y, Meguro K, Ikeda M, SEAD-J Study Group:Prediction of outcomes in MCI by using 18F-FDG-PET: A multicenter study.J Alzheimers Dis. 2015; 45(2):543-52.
  26. Kawakami S, Sato H, Sasaki AT, Tanabe HC, Yoshida Y, Saito M, Toyoda H, Sadato N, Kang Y (2016.1) The brain mechanisms underlying the perception of pungent taste of capsaicin and the subsequent autonomic responses.Front. Hum. Neurosci., 9, 720. DOI: 10.3389/fnhum.2015.00720
  27. Koike T, Tanabe HC, Okazaki S, Nakagawa E, Sasaki AT, Shimada K, Sugawara SK, Takahashi HK, Yoshihara K, Bosch-Bayard J, Sadato N (2016.1) Neural substrates of shared attention as a social memory: A hyperscanning functional magnetic resonance imaging study.NeuroImage, ePub ahead of print.DOI:10.1016/j.neuroimage.2015.09.076 *equally contributed
  28. Mizuno K, Tanaka M, Tanabe HC, Joudoi T, Kawatani J, Shigihara Y, Tomoda A, Miike T, Imai-Matsumura K, Sadato N, Watanabe Y (2015.9) Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome. NeuroImage Clinical. 9, 355-368. DOI: 10.1016/j.nicl.2015.09.001
  29. Kawamichi H, Yoshihara K, Sugawara SK, Matsunaga M, Makita K, Hamano YH, Tanabe HC, Sadato N (2016.4) Helping behavior induced by empathetic concern attenuates anterior cingulate activation in response to others’ distress.Soc. Neurosci. 11(2):109-122. DOI: 10.1080/17470919.2015.1049709
  30. Shimada K, Hirotani M, Yokokawa H, Yoshida H, Makita K, Yamazaki-Murase M, Tanabe HC, Sadato N (2015.5) Fluency-dependent cortical activation associated with speech production and comprehension in second language learners.Neuroscience. 2015; 300, 474-492. DOI: 10.1016
  31. Matsuyoshi D, Morita T, Kochiyama T, Tanabe HC, Sadato N, Kakigi R (2015.3) Dissociable cortical pathways for qualitative and quantitative mechanisms in the face inversion effect. J. Neurosci 2015;35(10), 4268-4279. DOI: 10.1523/JNEUROSCI.3960-14.
  32. Ogihara N, Amano H, Kikuchi T, Morita Y, Hasegawa K, Kochiyama T, Tanabe HC (2015.1) Towards digital reconstruction of fossil crania and brain morphology.Anthropol. Sci. 2015;123(1), 57-68. DOI: 10.1537/ase.141109.
  33. Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G. Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.Hum Mol Genet. 2015;24(2):314-29.
  34. Watanabe H, Atsuta N, Nakamura R, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Aoki M, Tsuji S, Nakano I, Kaji R, Sobue G. Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients.Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(3-4):230-6.
  35. Maesawa S, Bagarinao E, Fujii M, Futamura M, Motomura K, Watanabe H, Mori D, Sobue G, Wakabayashi T. Evaluation of resting state networks in patients with gliomas: connectivity changes in the unaffected side and its relation to cognitive function.PLoS One. 2015;10(2):e0118072.
  36. Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K. Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells.Cell Rep. 2015;11(4):592-604.
  37. Mitsui J, Matsukawa T, Sasaki H, (他23名), Watanabe H, Ito M, Sobue G, (他41名), Tsuji S. Variants associated with Gaucher disease in multiple system atrophy.Ann Clin Transl Neurol.2015 Apr;2(4):417-26.
  38. Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G. FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization.Nat Commun. 2015;6:7098.
  39. Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K.Position-specific binding of FUS to nascent RNA regulates mRNA length.Genes Dev. 2015;29(10):1045-57
  40. Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G. Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.Hum Mol Genet. 2015;24(21):5985-94.
  41. Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K. Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis.Am J Pathol. 2015;185(11):3053-65.
  42. Picher-Martel V, Dutta K, Phaneuf D, Sobue G, Julien JP. Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.Mol Brain. 2015;8(1):71.
  43. Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Ikegawa S, Kubo M, Yokoi D, Watanabe H, Ito M, Katsuno M, Izumi Y, Morita M, Kanai K, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Kawata A, Aoki M, Tsuji S, Nakashima K, Kaji R, Sobue G. A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.J Neurol Neurosurg Psychiatry. 2016; pii: jnnp-2015-311541. doi: 10.1136/jnnp-2015-311541.
  44. Kaneko N, Nakamura A, Washimi Y, Kato T, Sakurai T, Arahata Y, Bundo M, Takeda A, Niida S, Ito K, Toba K, Tanaka K, and Yanagisawa K:Novel plasma biomarker surrogating cerebral amyloid deposition.Proc Jpn Acad Ser B. 2014; 90(9): 353-64.
  45. Ishii K, Ito K, Nakanishi A, Kitamura S, Terashima A: Computer-assisted system for diagnosing degenerative dementia using cerebral blood flow SPECT and 3D-SSP: a multicenter study.Jpn J Radiol. 2014; 32(7):383-90.
  46. Yamane T, Ikari Y, Nishio T, Ishii K, Ishii K, Kato T, Ito K, D.H.S. Silverman, Senda M, Asada T, Arai H, Sugishita M, Iwatsubo T, and the J-ADNI Study Group. Visual-Statistical Interpretation of 18F-FDG-PET Images for Characteristic Alzheimer Patterns in a Multicenter Study: Inter-Rater Concordance and Relationship to Automated Quantitative Evaluation.AJNR Am J Neuroradiol. 2014; 35(2):244-9.
  47. Ota K, Oishi N, Ito K, Fukuyama H; the SEAD-J Study Group. A comparison of three brain atlases for MCI prediction.J Neurosci Methods. 2014; 221:139-50.
  48. Koike T, Tanabe HC, Sadato N (2015.1) “Hyperscanning neuroimaging technique to reveal the “two-in-one” system in social interactions.”Neurosci. Res., 90, 25-32. DOI: 10.1016/j.neures.2014.11.006
  49. Kawamichi H, Yoshihara K, Sasaki AT, Sugawara SK, Tanabe HC, Shinohara R, Sugisawa Y, Tokutake K, Mochizuki Y, Anme T, Sadato N (2014.9) “Perceiving active listening activates the reward system and improves the impression of relevant experiences.”,Soc. Neurosci. 2014;10, 16-26. DOI: 10.1080/17470919.2014.954732
  50. Sasai S, Homae F, Watanabe H, Sasaki AT, Tanabe HC, Sadato N, Taga G (2014.12) Frequency-specific network topologies in the resting human brain.Front. Hum. Neurosci. 2014;8, 1022. DOI: 10.3389/fnhum.
  51. Okamoto Y, Kitada R, Tanabe HC, Hayashi MJ, Kochiyama T, Munesue T, Ishitobi M, Saito DN, Yanaka HT, Omori M, Wada Y, Okazawa H, Sasaki AT, Morita T, Itakura S, Kosaka H, Sadato N (2014.10) Attenuation of the contingency detection effect in the extrastriate body area in autism spectrum disorder.Neurosci. Res. 2014;87,66-76. DOI: 10.1016/j.neures.
  52. Nakajima K, Minami T, Tanabe HC, Sadato N, Nakauchi S (2014.9) “Facial color processing in the face-selective regions: An fMRI study.”,Human Brain Mapping, 2014;35(9):4958-4964. DOI: 10.1002/hbm.22535
  53. Riku Y, Watanabe H, Yoshida M, Tatsumi S, Mimuro M, Iwasaki Y, Katsuno M, Iguchi Y, Masuda M, Senda J, Ishigaki S, Udagawa T, Sobue G. Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis.JAMA Neurol. 2014;71(2):172-9.
  54. Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, Fukata Y, Fukata M. Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis.J Neurosci. 2014;34(24):8151-63.
  55. Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G. Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy.Hum Mol Genet. 2014;23(13):3552-65.
  56. Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y, Nakatsuji H, Watanabe H, Yamamoto M, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G. Brugada syndrome in spinal and bulbar muscular atrophy.Neurology. 2014;82(20):1813-21.
  57. Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G. Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat Commun. 2013;4:1405.
  58. Mitsui J, Matsukawa T, Ishiura H, (他20名)Watanabe H, Ito M, Sobue G, (他48名): Mutations in COQ2 in familial and sporadic multiple-system atrophy. N Engl J Med. 2013;369:233-44.
  59. Miyazaki Y, Adachi H, Katsuno M, Minamiyama M, Jiang YM, Huang Z, Doi H, Matsumoto S, Kondo N, Iida M, Tohnai G, Tanaka F, Muramatsu S, Sobue G. Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2. Nat Med. 2012;18:1136-41.
  60. Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G. Naratriptan mitigates  CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med. 2012;18:1531-8.
  61. Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, (他23名) Sobue G: Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group. Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2010;9:875-84.
  62. Palazzolo I, Stack C, Kong L, Musaro A, Adachi H, Katsuno M, Sobue G, Taylor JP, Sumner CJ, Fischbeck KH, Pennuto M. Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron. 2009;63:316-28.
  63. Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G. Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy. Ann Neurol. 2009;65:140-50.
  64. Katsuno M, Adachi H, Sobue G. Getting a handle on Huntington’s disease: the case for cholesterol. Nat Med. 2009;15:253-4.
  65. Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med. 2005;11:1088-95.
  66. Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G.  Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci U S A. 2005;102:16801-6.
  67. Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, Sobue G. Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat Med. 2003;9:768-73.
  68. Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi Y, Doyu M, Sobue G. Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron. 2002;35:843-54.

A01-2

  1. Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A. Small-animal PET imaging of tau pathology with 18F-THK5117 in 2 transgenic mouse models.J Nucl Med. 2016 57: 792-798.
  2. Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y. Advances in the Development of Tau PET Radiotracers and Their Clinical Applications.Ageing Res Rev 2016 (in press)
  3. Furukawa K, Ishiki A, Tomita N, Onaka Y, Saito H, Nakamichi T, Hara K, Kusano Y, Ebara M, Arata Y, Sakota M, Miyazawa I, Totsune T, Okinaga S, Okamura N, Kudo Y, Arai H. Introduction and overview of the special issue “Brain imaging and aging”: The new era of neuroimaging in aging research.Ageing Res Rev. 2016 (in press)
  4. Harada R, Okamura N, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y. Characteristics of tau and its ligands in PET imaging.Biomolecules. 2016; 6: 7.
  5. Harada R, Furumoto S, Yoshikawa T, Ishikawa Y, Shibuya K, Okamura N, Ishiwata K, Iwata R, Yanai K. Synthesis and characterization of 18F-interleukin-8 using a cell-free translation system and 18F-fluoro-L-proline.J Nucl Med. 2016 57: 634-639.
  6. Tago T, Furumoto S, Okamura N, Harada R, Adachi H, Ishikawa Y, Yanai K, Iwata R, Kudo Y. Structure-activity relationship of 2-Arylquinolines as PET imaging tracers for tau pathology in Alzheimer’s disease.J Nucl Med. 2016; 57: 608-614.
  7. Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y. 18F-THK5351: A novel PET radiotracer for imaging neurofibrillary pathology in Alzheimer’s disease.J Nucl Med. 2016; 57: 208-214.
  8. Tago T, Furumoto S, Okamura N, Harada R, Adachi H, Ishikawa Y, Yanai K, Iwata R, Kudo Y. Preclinical evaluation of [18F]THK-5105 enantiomers: Effects of chirality on its effectiveness as a tau imaging radiotracer.Mol Imaging Biol. 2016; 18: 258-266.
  9. Villemagne VL, Okamura N. Tau imaging in the study of ageing, Alzheimer’s disease, and other neurodegenerative conditions.Curr Opin Neurobiol. 2016; 36: 43-51.
  10. Ishiki A, Okamura N, Furukawa K, Furumoto S, Harada R, Tomita N, Hiraoka K, Watanuki S, Ishikawa Y, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Kudo Y, Arai H. Longitudinal assessment of tau pathology in patients with Alzheimer’s disease using [18F]THK-5117 positron emission tomography.PLoS One. 2015; 10: e0140311.
  11. Hiraoka K, Narita W, Kikuchi H, Baba T, Kanno S, Iizuka O, Tashiro M, Furumoto S, Okamura N, Furukawa K, Arai H, Iwata R, Mori E, Yanai K. Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus.J Neurol Sci. 2015; 356: 124-128.
  12. Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K. Quantitative kinetic analysis of PET amyloid imaging agents [11C]BF227 and [18F]FACT in human brain.Nucl Med Biol. 2015;42: 734-744.
  13. Lemoine L, Saint-Aubert L, Marutle A, Antoni G, Eriksson JP, Ghetti B, Okamura N, Nennesmo I, Gillberg PG, Nordberg A. Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue.Acta Neuropathol Commun. 2015; 3: 40.
  14. Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y. [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease.Eur J Nucl Med Mol Imaging. 2015; 42: 1052-1061.
  15. Li Y, Tsui W, Rusinek H, Butler T, Mosconi L, Pirraglia E, Mozley D, Vallabhajosula S, Harada R, Furumoto S, Furukawa K, Arai H, Kudo Y, Okamura N, de Leon MJ. Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. J Nucl Med. 2015;56: 270-273.
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